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Total Synthesis of (+)‐Camptothecin

1996; Volume: 35; Issue: 15 Linguagem: Inglês

10.1002/anie.199616921

0570-0833

Marco A. Ciufolini, Frank Roschangar,

Synthesis and pharmacology of benzodiazepine derivatives

A quinoline, a chiral aldehyde, and cyanoacetamide are the three components (see retrosynthesis below) merged in five steps to afford the antitumor agent ( + )-camptothecin (CPT, 1). The overall yield of CPT is 30% over ten steps from dimethyl 2-ethylmalonate (the precursor of the aldehyde component). MOM = methoxymethyl.