Portal de Periódicos da CAPES

Biotransformation of arteannuic acid into arteannuin-B and artemisinin in Artemisia annua

1993; Elsevier BV; Volume: 34; Issue: 5 Linguagem: Inglês

10.1016/0031-9422(91)80019-w

1873-3700

R. S. Sangwan, Krishna Agarwal, R. Luthra, Raghunath S. Thakur, Neelam S. Sangwan,

Computational Drug Discovery Methods

In Artemisia annua, [14C]arteannuic acid was incorporated into arteannuin-B as well as artemisinin, both in vivo and in a cell free system. Fe2, 2-oxoglutarate, and peroxidase-H2O2 enhanced the incorporations under in vitro conditions. The results suggest that arteannuic acid might be a common precursor for arteannuin-B and artemisinin synthesis.