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Walking with myosin V

2005; Elsevier BV; Volume: 18; Issue: 1 Linguagem: Inglês

10.1016/j.ceb.2005.12.014

1879-0410

James R. Sellers, Claudia Veigel,

Cellular Mechanics and Interactions

The cytoplasm of cells is teeming with vesicles and other cargo that are moving along tracks of microtubules or actin filaments, powered by myosins, kinesins and dyneins. Myosin V has been implicated in several types of intracellular transport. The mechanism by which myosin V moves processively along actin filaments has been the subject of many biophysical and biochemical studies and a consensus is starting to emerge about how this minute molecular motor operates.