Low-dose megavoltage cone-beam computed tomography for lung tumors using a high-efficiency image receptor
2006; Wiley; Volume: 33; Issue: 9 Linguagem: Inglês
10.1118/1.2222075
ISSN2473-4209
AutoresJussi Sillanpaa, Jenghwa Chang, G Mageras, Ellen Yorke, Fernando De Arruda, Kenneth E. Rosenzweig, Peter R. T. Munro, E. Seppi, John M. Pavkovich, Howard Amols,
Tópico(s)Advanced X-ray and CT Imaging
ResumoMedical PhysicsVolume 33, Issue 9 p. 3489-3497 Radiation therapy physics Low-dose megavoltage cone-beam computed tomography for lung tumors using a high-efficiency image receptor Jussi Sillanpaa, Jussi Sillanpaa Department of Medical Physics, Memorial Sloan–Kettering Cancer Center, New York, New York 10021Search for more papers by this authorJenghwa Chang, Jenghwa Chang Department of Medical Physics, Memorial Sloan–Kettering Cancer Center, New York, New York 10021 Author to whom correspondence should be addressed. Jenghwa Chang, Ph.D., Memorial Sloan-Kettering Cancer Center, Medical Physics Department, 1275 York Avenue, New York, NY 10021. Tel: 212-639-6036. Electronic mail: [email protected]Search for more papers by this authorGikas Mageras, Gikas Mageras Department of Medical Physics, Memorial Sloan–Kettering Cancer Center, New York, New York 10021Search for more papers by this authorEllen Yorke, Ellen Yorke Department of Medical Physics, Memorial Sloan–Kettering Cancer Center, New York, New York 10021Search for more papers by this authorFernando De Arruda, Fernando De Arruda Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021Search for more papers by this authorKenneth E. Rosenzweig, Kenneth E. Rosenzweig Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021Search for more papers by this authorPeter Munro, Peter Munro Ginzton Technology Center, Varian Medical Systems, Mountain View, California 94043Search for more papers by this authorEdward Seppi, Edward Seppi Ginzton Technology Center, Varian Medical Systems, Mountain View, California 94043Search for more papers by this authorJohn Pavkovich, John Pavkovich Ginzton Technology Center, Varian Medical Systems, Mountain View, California 94043Search for more papers by this authorHoward Amols, Howard Amols Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021Search for more papers by this author Jussi Sillanpaa, Jussi Sillanpaa Department of Medical Physics, Memorial Sloan–Kettering Cancer Center, New York, New York 10021Search for more papers by this authorJenghwa Chang, Jenghwa Chang Department of Medical Physics, Memorial Sloan–Kettering Cancer Center, New York, New York 10021 Author to whom correspondence should be addressed. Jenghwa Chang, Ph.D., Memorial Sloan-Kettering Cancer Center, Medical Physics Department, 1275 York Avenue, New York, NY 10021. Tel: 212-639-6036. Electronic mail: [email protected]Search for more papers by this authorGikas Mageras, Gikas Mageras Department of Medical Physics, Memorial Sloan–Kettering Cancer Center, New York, New York 10021Search for more papers by this authorEllen Yorke, Ellen Yorke Department of Medical Physics, Memorial Sloan–Kettering Cancer Center, New York, New York 10021Search for more papers by this authorFernando De Arruda, Fernando De Arruda Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021Search for more papers by this authorKenneth E. Rosenzweig, Kenneth E. Rosenzweig Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021Search for more papers by this authorPeter Munro, Peter Munro Ginzton Technology Center, Varian Medical Systems, Mountain View, California 94043Search for more papers by this authorEdward Seppi, Edward Seppi Ginzton Technology Center, Varian Medical Systems, Mountain View, California 94043Search for more papers by this authorJohn Pavkovich, John Pavkovich Ginzton Technology Center, Varian Medical Systems, Mountain View, California 94043Search for more papers by this authorHoward Amols, Howard Amols Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021Search for more papers by this author First published: 31 August 2006 https://doi.org/10.1118/1.2222075Citations: 23 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract We report on the capabilities of a low-dose megavoltage cone-beam computed tomography (MV CBCT) system. The high-efficiency image receptor consists of a photodiode array coupled to a scintillator composed of individual crystals. The CBCT system uses the 6 MV beam from a linear accelerator. A synchronization circuit allows us to limit the exposure to one beam pulse [0.028 monitor units (MU)] per projection image. 150–500 images ( total) are collected during a one-minute scan and reconstructed using a filtered backprojection algorithm. Anthropomorphic and contrast phantoms are imaged and the contrast-to-noise ratio of the reconstruction is studied as a function of the number of projections and the error in the projection angles. The detector dose response is linear ( value 0.9989). A 2% electron density difference is discernible using 460 projection images and a total exposure of (corresponding to a maximum absorbed dose of about in a patient). We present first patient images acquired with this system. Tumors in lung are clearly visible and skeletal anatomy is observed in sufficient detail to allow reproducible registration with the planning kV CT images. The MV CBCT system is shown to be capable of obtaining good quality three-dimensional reconstructions at relatively low dose and to be clinically usable for improving the accuracy of radiotherapy patient positioning. REFERENCES 1C. W. Hurkmans, P. Remeijer, J. V. Lebesque, and B. J. Mijnheer, "Set-up verification using portal imaging; review of current clinical practice," Radiother. Oncol. 58, 105–120 (2001). 10.1016/S0167-8140(00)00260-7 CASPubMedWeb of Science®Google Scholar 2S. Erridge, Y. Seppenwoolde, S. Muller, M. van Herk, K. De Jaeger, J. Belderbos, L. Boersma, and J. 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