Narrowing the critical region for a rhabdoid tumor locus in 22q11
1996; Wiley; Volume: 16; Issue: 2 Linguagem: Inglês
10.1002/(sici)1098-2264(199606)16
ISSN1098-2264
AutoresJaclyn A. Biegel, Cindy Allen, Kazuhiko Kawasaki, Nobuyoshi Shimizu, Marcia L. Budarf, Callum J. Bell,
Tópico(s)interferon and immune responses
ResumoGenes, Chromosomes and CancerVolume 16, Issue 2 p. 94-105 Research Article Narrowing the critical region for a rhabdoid tumor locus in 22q11 Jaclyn A. Biegel, Corresponding Author Jaclyn A. Biegel Division of Human Genetics and Molecular Biology, The Children's Hospital of Philadelphia, Philadelphia, PennsylvaniaRoom 1002, Abramson Research Center, The Children's Hospital of Philadephia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USASearch for more papers by this authorCindy S. Allen, Cindy S. Allen Division of Human Genetics and Molecular Biology, The Children's Hospital of Philadelphia, Philadelphia, PennsylvaniaSearch for more papers by this authorKazuhiko Kawasaki, Kazuhiko Kawasaki Department of Molecular Biology, Keio University, Tokyo, JapanSearch for more papers by this authorNobuyoshi Shimizu, Nobuyoshi Shimizu Department of Molecular Biology, Keio University, Tokyo, JapanSearch for more papers by this authorMarcia L. Budarf, Marcia L. Budarf Division of Human Genetics and Molecular Biology, The Children's Hospital of Philadelphia, Philadelphia, PennsylvaniaSearch for more papers by this authorCallum J. Bell, Callum J. Bell Division of Human Genetics and Molecular Biology, The Children's Hospital of Philadelphia, Philadelphia, PennsylvaniaSearch for more papers by this author Jaclyn A. Biegel, Corresponding Author Jaclyn A. Biegel Division of Human Genetics and Molecular Biology, The Children's Hospital of Philadelphia, Philadelphia, PennsylvaniaRoom 1002, Abramson Research Center, The Children's Hospital of Philadephia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USASearch for more papers by this authorCindy S. Allen, Cindy S. Allen Division of Human Genetics and Molecular Biology, The Children's Hospital of Philadelphia, Philadelphia, PennsylvaniaSearch for more papers by this authorKazuhiko Kawasaki, Kazuhiko Kawasaki Department of Molecular Biology, Keio University, Tokyo, JapanSearch for more papers by this authorNobuyoshi Shimizu, Nobuyoshi Shimizu Department of Molecular Biology, Keio University, Tokyo, JapanSearch for more papers by this authorMarcia L. Budarf, Marcia L. Budarf Division of Human Genetics and Molecular Biology, The Children's Hospital of Philadelphia, Philadelphia, PennsylvaniaSearch for more papers by this authorCallum J. Bell, Callum J. Bell Division of Human Genetics and Molecular Biology, The Children's Hospital of Philadelphia, Philadelphia, PennsylvaniaSearch for more papers by this author First published: June 1996 https://doi.org/10.1002/(SICI)1098-2264(199606)16:2 3.0.CO;2-YCitations: 88AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Rhabdoid tumor is a rare malignant neoplasm of childhood that may occur in various locations, including the central nervous system and the kidney. Previous cytogenetic studies of primary rhabdoid tumors have demonstrated monosomy or deletion of chromosome 22 and have implicated the presence of a rhabdoid tumor suppressor gene that maps to 22q. We have employed fluorescence in situ hybridization to narrow the region for this locus in four rhabdoid tumor cell lines with translocations or deletions involving chromosome segment 22q11. The completion of a cosmid and yeast artificial chromosome contig spanning the immunoglobulin lambda gene locus to BCR has allowed us to map a critical region for a rhabdoid tumor gene to a 500 kb span of chromosome segment 22q11. Genes Chromosom Cancer 16:94–105 (1996). © 1996 Wiley-Liss, Inc. Citing Literature Volume16, Issue2June 1996Pages 94-105 RelatedInformation
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