Portal de Periódicos da CAPES

A zinc(II)–glycine complex is an effective inducer of metallothionein and removes oxidative stress

2006; Elsevier BV; Volume: 45; Issue: 1 Linguagem: Inglês

10.1016/j.jdermsci.2006.08.009

1873-569X

Hitoshi Masaki, Yasunobu Ochiai, Yuri Okano, Akiko Yagami, Hirohiko Akamatsu, Kayoko Matsunaga, Hiromu Sakurai, Keiichiro Suzuki,

Iron Metabolism and Disorders

Metallothionein (MT) is a cysteine-rich low molecular peptide (6–7 kDa) that is widely distributed in a broad range of eukaryotic species from yeast to mammals [ [1] Miles A.T. Hawksworth G.M. Beattie J.H. Rodilla V. Induction, regulation, degradation, and biological significance of mammalian metallothioneins. Crit Rev Biochem Mol Biol. 2000; 35: 35-70 Crossref PubMed Scopus (396) Google Scholar ]. Both in mice and in humans, there are four classes of quite similar MT peptides, MT-I to MT-IV. MT-I and MT-II are widely expressed in all tissues, whereas MT-III and MT-IV are expressed mainly in the central nervous system and in squamous epithelia, respectively [ 2 Waalkes M.P. Klaassen C.D. Concentration of metallothionein in major organs of rats after administration of various metals. Fundam Appl Toxicol. 1985; 5: 473-477 Crossref PubMed Scopus (121) Google Scholar , 3 Palmiter R.D. Findley S.D. Whitmore T.E. Durnam D.M. MT-III, a brain-specific member of the metallothionein gene family. Proc Natl Acad Sci USA. 1992; 89: 6333-6337 Crossref PubMed Scopus (550) Google Scholar ]. Basically, MT serves as an endogenous detoxicant peptide against toxicity caused by heavy metals, especially cadmium, mercury and zinc [ [4] Durnam D.M. Palmiter R.D. Analysis of the detoxification of heavy metal ions by mouse metallothionein. Experientia Suppl. 1987; 52: 457-463 Crossref PubMed Scopus (36) Google Scholar ]. Also, recent research demonstrated that MT worked as an internal scavenger against reactive oxygen species [ [5] Hanada K. Photoprotective role of metallothionein in UV-injury—metallothionein-null mouse exhibits reduced tolerance against ultraviolet-B. J Dermatol Sci. 2000; 23: S51-S56 Abstract Full Text Full Text PDF PubMed Scopus (12) Google Scholar ]. Several studies have reported that induction of MT in keratinocytes by chemical inducers, cold treatment, Vitamin D3 or β-thujaplicin, reduces UVB-induced cell damage [ 6 Ota T. Hanada K. Hashimoto I. The effect of cold stress on UVB injury in mouse skin and cultured keratinocytes. Photochem Photobiol. 1996; 64: 984-987 Crossref PubMed Scopus (17) Google Scholar , 7 Hanada K. Sawamura D. Nakano H. Hashimoto I. Possible role of 1,25-dihydroxyvitamin D3-induced metallothionein in photoprotection against UVB injury in mouse skin and cultured rat keratinocytes. J Dermatol Sci. 1995; 9: 203-208 Abstract Full Text PDF PubMed Scopus (69) Google Scholar , 8 Lee J. Youn J.I. The photoprotective effect of 1,25-dihydroxyvitamin D3 on ultraviolet light B-induced damage in keratinocyte and its mechanism of action. J Dermatol Sci. 1998; 18: 11-18 Abstract Full Text Full Text PDF PubMed Scopus (78) Google Scholar , 9 Baba T. Nakano H. Tamai K. Sawamura D. Hanada K. Hashimoto I. et al. Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes. J Invest Dermatol. 1998; 110: 24-28 Crossref PubMed Scopus (62) Google Scholar ].