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A polymer-supported thionating reagent

2001; Royal Society of Chemistry; Issue: 4 Linguagem: Inglês

10.1039/b008814p

1472-7781

Steven V. Ley, Andrew G. Leach, Richard Storer,

Multicomponent Synthesis of Heterocycles

A new polymer-supported reagent for the conversion of carbonyls to thiocarbonyls has been developed and its use demonstrated on a range of amides. Secondary or tertiary amides are converted cleanly and efficiently through to the corresponding thioamides and primary amides are converted to the corresponding nitriles. The reactions can be facilitated by conventional heating. However, if microwave heating is used, in the presence of an ionic liquid, enhanced reaction rates are achieved.