Involvement of dynorphin and the kappa opioid receptor in feeding
1983; Elsevier BV; Volume: 4; Issue: 6 Linguagem: Inglês
10.1016/0196-9781(83)90069-4
ISSN1873-5169
AutoresJohn E. Morley, Allen S. Levine,
Tópico(s)Pharmacological Effects and Assays
ResumoDynorphin-(1–17) produces a highly specific increase in food ingestion. Similar enhancement of food ingestion is found with dynorphin fragments (1–10), (1–11), (1–13) and (3–13) but not with (1–8) and (1–9). Dynorphin B (rimorphin) also enhances food intake. The highly specific kappa agonist U-50,488 also enhances food intake as do a number of other kappa-opiate receptor agonists. These studies provided further support for the role of a highly specific dynorphin-kappa opioid receptor in the modulation of feeding.
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