Lipoatrophic Panniculitis: A Possible Autoimmune Inflammatory Disease of Fat
1987; American Medical Association; Volume: 123; Issue: 12 Linguagem: Inglês
10.1001/archderm.1987.01660360090018
ISSN1538-3652
Autores Tópico(s)Autoimmune Bullous Skin Diseases
Resumo• We observed three children with a clinically similar presentation of erythematous nodules that expanded centrifugally leaving lipoatrophy. Areas of lipoatrophy coalesced, resulting in clinical pictures similar to partial or total lipodystrophy. Histologic study revealed a lobular panniculitis with a mixed infiltrate of lymphocytes and mononuclear phagocytes. Of these three children, one had insulin-dependent diabetes mellitus and Hashimoto's thyroiditis, one developed juvenile rheumatoid arthritis, and the third developed insulin-dependent diabetes mellitus, suggesting that the pathogenic mechanism may be an expression of autoimmunity. ( Arch Dermatol 1987;123:1662-1666)
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