Reversible Renal Failure and Nephrotic Syndrome Associated with Nonsteroidal Anti-Inflammatory Drugs
1979; Massachusetts Medical Society; Volume: 301; Issue: 23 Linguagem: Inglês
10.1056/nejm197912063012306
ISSN1533-4406
AutoresJ. Brezin, Sheila Moriber Katz, Allen B. Schwartz, Joel L. Chinitz,
Tópico(s)Metabolism and Genetic Disorders
ResumoREVERSIBLE renal failure and nephrotic syndrome developed in three patients taking therapeutic doses of either fenoprofen or naproxen; both drugs are phenylalkanoic acids used as anti-inflammatory agents. We present here the clinical and pathological features of this complication.Case ReportsA 51-year-old woman (Patient 1) was admitted to the hospital on May 7, 1977, because of nausea, dizziness, and swelling of her legs for several days. She had a five-year history of rheumatoid arthritis. Since August, 1976, she had been taking fenoprofen, 1800 mg to 2400 mg daily, and prednisone, 5 mg daily. Gold therapy preceded the use of fenoprofen, . . .
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