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Synthesis of a novel series of 2,3,4-trisubstituted oxazolidines designed by isosteric replacement or rigidification of the structure and cytotoxic evaluation

2014; Royal Society of Chemistry; Volume: 5; Issue: 11 Linguagem: Inglês

10.1039/c4md00136b

2040-2511

Saulo Fernandes de Andrade, Cláudia Salviano Teixeira, Jonas Pereira Ramos, Marcela Silva Lopes, Rodrigo Maia de Pádua, Mônica Cristina Oliveira, Elaine M. Souza–Fagundes, Ricardo José Alves,

Organic Chemistry Cycloaddition Reactions

Rigidification of the structure of 2,3,4-trisubstituted oxazolidines enhances the activity against LNCaP cells without affecting normal cell proliferation.