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BIBTEX RIS

Yeast as a model to study mitochondrial mechanisms in ageing

2010; Elsevier BV; Volume: 131; Issue: 7-8 Linguagem: Inglês

10.1016/j.mad.2010.04.008

ISSN

1872-6216

Autores

Mário H. Barros, Fernanda Marques da Cunha, Graciele Almeida de Oliveira, Erich Birelli Tahara, Alicia J. Kowaltowski,

Tópico(s)

Fungal and yeast genetics research

Resumo

Despite the fact that ageing necessarily displays unique aspects in a single-cell organism, yeast, in particular Saccharomyces cerevisiae, are useful as model organisms to study ageing. Here we review mitochondrial characteristics involved in yeast longevity, including biogenesis, autophagy, respiration and oxidative phosphorylation, nutrient sensing, mitochondria-nuclear signaling, redox state and mitochondrial DNA integrity. Altogether, the yeast model unearths a rich and complex network involving many mitochondrial functions in ageing, and uncovers physiological and genetic mechanisms capable of extending lifespan in this model which may be shared with more complex organisms.

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