Produção Nacional
Revisado por pares
Integrated Proteomics Identified Up-Regulated Focal Adhesion-Mediated Proteins in Human Squamous Cell Carcinoma in an Orthotopic Murine Model
2014; Public Library of Science; Volume: 9; Issue: 5 Linguagem: Inglês
10.1371/journal.pone.0098208
ISSN1932-6203
AutoresDaniela Campos Granato, Mariana R. Zanetti, Rebeca Kawahara, Sami Yokoo, Romênia R. Domingues, Annelize Zambon Barbosa Aragão, Michelle Agostini, Marcelo Falsarella Carazzolle, Ramón Vidal, Isadora Luana Flores, Johanna Korvala, Nilva K. Cervigne, Alan Roger Santos‐Silva, Ricardo D. Coletta, Edgard Graner, Nicholas E. Sherman, Adriana Franco Paes Leme,
Tópico(s)Cancer, Hypoxia, and Metabolism
ResumoUnderstanding the molecular mechanisms of oral carcinogenesis will yield important advances in diagnostics, prognostics, effective treatment, and outcome of oral cancer. Hence, in this study we have investigated the proteomic and peptidomic profiles by combining an orthotopic murine model of oral squamous cell carcinoma (OSCC), mass spectrometry-based proteomics and biological network analysis. Our results indicated the up-regulation of proteins involved in actin cytoskeleton organization and cell-cell junction assembly events and their expression was validated in human OSCC tissues. In addition, the functional relevance of talin-1 in OSCC adhesion, migration and invasion was demonstrated. Taken together, this study identified specific processes deregulated in oral cancer and provided novel refined OSCC-targeting molecules.
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