Studies of the kinetics of the reduction of chromate by glutathione and related thiols
1992; Elsevier BV; Volume: 11; Issue: 24 Linguagem: Inglês
10.1016/s0277-5387(00)83664-5
ISSN1873-3719
AutoresPaul O’Brien, Guofang Wang, Peter B. Wyatt,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoThe reduction of chromate by glutathione, its mono- and diethyl esters, L-cysteine, 2-mercapto-propionic acid and mercapto-succinic acid has been studied. The empirical rate law kobs = ab[Thiol]2/(1 + b[Thiol]) is obeyed by all of these thiols, at neutral pH. No evidence could be obtained for a first-order pathway in glutathione under these conditions. These observations are used to comment on the stability of intermediates potentially important in explaining chromate toxicity.
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