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Crystal Growth of Sodium Acid Urate

1965; Elsevier BV; Volume: 54; Issue: 3 Linguagem: Inglês

10.1002/jps.2600540308

1520-6017

Donald J. Allen, George Milosovich, Albert M. Mattocks,

Chemical Thermodynamics and Molecular Structure

Symptoms of gouty arthritis are caused by the deposition of needle crystals of sodium acid urate in intrasynovial fluids. Since only the needle habit causes the inflammatory reaction, any compound that retards needle axis growth may be a potential drug for this disease. This study was designed to test a number of compounds for their inhibitory effect on the needle axis growth rate of sodium acid urate crystals. Instrumentation for single crystal alignment and crystal growth measurement is described. Growth data are presented as a function of the degree of supersaturation. The inhibitory effect of benzalkonium chloride was measured. Photomicrographs of crystals, grown in the presence of surface-active agents, show the habit changes which can be obtained. Symptoms of gouty arthritis are caused by the deposition of needle crystals of sodium acid urate in intrasynovial fluids. Since only the needle habit causes the inflammatory reaction, any compound that retards needle axis growth may be a potential drug for this disease. This study was designed to test a number of compounds for their inhibitory effect on the needle axis growth rate of sodium acid urate crystals. Instrumentation for single crystal alignment and crystal growth measurement is described. Growth data are presented as a function of the degree of supersaturation. The inhibitory effect of benzalkonium chloride was measured. Photomicrographs of crystals, grown in the presence of surface-active agents, show the habit changes which can be obtained.