Hydroaminomethylation with Novel Rhodium–Carbene complexes: An Efficient Catalytic Approach to Pharmaceuticals
2006; Wiley; Volume: 13; Issue: 5 Linguagem: Inglês
10.1002/chem.200601155
ISSN1521-3765
AutoresMoballigh Ahmed, Cathleen Buch, Lucie Routaboul, Ralf Jackstell, Holger Klein, Anke Spannenberg, Matthias Beller,
Tópico(s)Catalytic Cross-Coupling Reactions
ResumoStarting from [{Rh(cod)Cl}(2)] and 1,3-dimesitylimidazole-2-ylidenes the novel [RhCl(cod)(carbene)] complexes 1-5 have been synthesized, characterized, and tested in the hydroaminomethylation of aromatic olefins. The influence of different ligands and reaction parameters on the catalytic activity was investigated in detail applying 1,1-diphenylethylene and piperidine as a model system. The scope and limitations of the novel catalysts is shown in the preparation of 16 biologically active 1-amino-3,3-diarylpropenes. In general, high chemo- and regioselectivity as well as good yields of the desired products were achieved.
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