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Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

1990; Nature Portfolio; Volume: 348; Issue: 6297 Linguagem: Inglês

10.1038/348137a0

1476-4687

Pil-Jung Kang, Joachim Ostermann, Jeffery Shilling, Walter Neupert, Elizabeth A. Craig, Nikolaus Pfanner,

ATP Synthase and ATPases Research

By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the matrix.