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Transvaginal estriol administration in postmenopausal women: a double blind comparative study of two different doses

1995; Elsevier BV; Volume: 22; Issue: 3 Linguagem: Inglês

10.1016/0378-5122(95)00943-f

1873-4111

Francesco Bottiglione, Annibale Volpe, Gaetano Esposito, Domenico De Aloysio,

Menstrual Health and Disorders

A group of 72 postmenopausal women were treated for 4 weeks with vaginal suppositories containing 0.5 or 1.0 mg of estriol. The two different doses achieved an identical significant improvement of urogenital symptoms. while a dose-related effect seen to be on climacteric complaints, according to a good absorption of estriol by the vaginal epithelium. Minimal side effects were observed and the safety of vaginal estriol treatment could advise further study about the effect of this kind of treatment on the climacteric syndrome.