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Transcutaneous Glucose Sensing by Surface-Enhanced Spatially Offset Raman Spectroscopy in a Rat Model

2010; American Chemical Society; Volume: 82; Issue: 20 Linguagem: Inglês

10.1021/ac101951j

1520-6882

Jonathan M. Yuen, Nilam C. Shah, Joseph T. Walsh, Matthew R. Glucksberg, Richard P. Van Duyne,

Electrochemical sensors and biosensors

This letter presents the first quantitative, in vivo, transcutaneous glucose measurements using surface enhanced Raman spectroscopy (SERS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in a Sprague−Dawley rat. The glucose concentration was monitored in the interstitial fluid. SER spectra were collected from the sensor chip through the skin using spatially offset Raman spectroscopy (SORS). The combination of SERS and SORS is a powerful new approach to the challenging problem of in vivo metabolite and drug sensing.