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BIBTEX RIS

t(10;16)(q22;p13) and MORF ‐ CREBBP fusion is a recurrent event in acute myeloid leukemia

2003; Wiley; Volume: 36; Issue: 4 Linguagem: Inglês

10.1002/gcc.10174

ISSN

1098-2264

Autores

J.L. Vizmanos, María José Larráyoz, Idoya Lahortiga, Filomena Floristán, Carmen Álvarez-Domínguez, María D. Odero, Francisco J. Novo, Marı́a José Calasanz,

Tópico(s)

Multiple Myeloma Research and Treatments

Resumo

Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML.

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