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Studies on the constituents of leguminous plants. XII. The structures of new triterpenoid saponins from Wistaria brachybotrys SIEB. et ZUCC.

1989; Pharmaceutical Society of Japan; Volume: 37; Issue: 10 Linguagem: Inglês

10.1248/cpb.37.2731

1347-5223

Takao Konoshima, Mutsuo Kozuka, Mitsumasa Haruna, Kazuo Ito, Takeatsu Kimura, Harukuni Tokuda,

Botanical Research and Chemistry

Four new triterpenoid saponins (wistariasaponins A, B1, B2 and C) were isolated as methyl ester forms from the knots of Wistaria brachybotrys (Leguminosae), and their structures were characterized as 3-O-[α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl(1→2)-β-D-glucuronopyranosyl]wistariasapogenol A, 3-O[α-L-rhamnopyranosyl(1→2)-β-D-xylopyranosyl(1→2)-β-D-glucuronopyranosyl]wistariasapogenol B, 3-O-[α-L-rhamnopyranosyl(1→2)-β-D-galactopyranosyl(1→2)-β-D-glucuronopyranosyl]wistariasapogenol B and 3-O-[α-L-rhamnopyranosyl(1→2)-β-D-xylopyranosyl-(1→2)-β-D-glucuronopyranosyl]soyasapogenol B, respectively, on the basis of chemical and physicochemical evidence. The inhibitory effects of these saponins and sapogenols on Epstein-Barr virus activation induced by a tumor promoter were also tested for the primary screening of anti-tumor promoting activities.