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DYSPLASTIC NEVI, CUTANEOUS MELANOMA, AND GYNECOLOGIC DISORDERS

1992; Wiley; Volume: 31; Issue: 5 Linguagem: Inglês

10.1111/j.1365-4362.1992.tb03948.x

1365-4632

Rose E. Frisch, Grace Wyshak, Lee S. Albert, Arthur J. Sober,

Nonmelanoma Skin Cancer Studies

Abstract We compared the frequency of reproductive system diseases and disorders among 206 female patients with dysplastic nevi (DN), and/or melanoma, in comparison with random samples of women of comparable age without melanoma. The highest odds ratio (OR) for these age‐related diseases and reproductive disorders occurs among the youngest age group of the patients with DN alone (mean age 35.1 ± 1.2 yr): 44.2% of the DN subjects had one or more reproductive disorders compared with 19.8% of the random sample (OR 3.2, 95% CL (1.6, 6.5), P < 0.001). The patients with melanoma and DN (mean age 41.5 ± 1.4 yr) also had a significantly greater percentage of subjects with one or more reproductive disorders, though less so than the DN subjects: 49.4% compared to 33.7% (OR 1.9, 95% CL (1.1, 3.3), P = 0.02).