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Function and regulation of Aurora/Ipl1p kinase family in cell division

2003; Springer Nature; Volume: 13; Issue: 2 Linguagem: Inglês

10.1038/sj.cr.7290152

1748-7838

Yu Ke, Zhen Dou, Jie Zhang, Xuebiao Yao,

Cellular transport and secretion

During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p family, a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis. This article highlights the function and regulation of Aurora/Ipl1p family in mitosis and provides potential links between aberrant regulation of Aurora/Ipl1p kinases and pathogenesis of human cancer.