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Flavonol glycosides from Costus spicatus

2000; Elsevier BV; Volume: 53; Issue: 1 Linguagem: Inglês

10.1016/s0031-9422(99)00441-0

1873-3700

Bernadete Pereira da Silva, Róbson Roney Bernardo, José Paz Parente,

Antioxidant Activity and Oxidative Stress

Two flavonol diglycosides, tamarixetin 3-O-neohesperidoside, kaempferide 3-O-neohesperidoside and the known quercetin 3-O-neohesperidoside, together with six other known flavonoids were isolated from the leaves of Costus spicatus and their structures were elucidated by a combination of spectroscopic and chemical methods. The flavonol diglycosides were evaluated for inhibitory activity of nitric oxide production by activated macrophages (Fig. 1 Fig. 1. Inhibitory activity on nitric oxide production of activated macrophages by compounds 1 (⋅), 2 (□) and 3 (▵). Data points presented as mean ± SD, ∗p < 0.01, ∗p < 0.05. Significant difference from control group.