Adoptive T cell therapy of cancer
2010; Elsevier BV; Volume: 22; Issue: 2 Linguagem: Inglês
10.1016/j.coi.2010.01.020
ISSN1879-0372
AutoresMalcolm K. Brenner, Helen E. Heslop,
Tópico(s)Viral Infectious Diseases and Gene Expression in Insects
ResumoAdoptive transfer of T cells specific for antigens expressed on tumor cells is an attractive strategy for producing targeted and long-lived anti-tumor activity. T cell therapies have shown activity in selected clinical applications but broader application is limited by inadequate persistence of transferred T cells and by tumor-evasion strategies. Current research focuses on defining the optimum type of cell for transfer, genetically modifying infused T cells to augment function and overcome tumor evasion strategies and modulating the host environment.
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