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Transfer of extracellular vesicles during immune cell‐cell interactions

2012; Wiley; Volume: 251; Issue: 1 Linguagem: Inglês

10.1111/imr.12013

1600-065X

Cristina Gutiérrez‐Vázquez, Carolina Villarroya‐Beltri, Marı́a Mittelbrunn, Francisco Sánchez‐Madrid,

RNA Interference and Gene Delivery

Summary The transfer of molecules between cells during cognate immune cell interactions has been reported, and recently a novel mechanism of transfer of proteins and genetic material such as small RNA between T cells and antigen‐presenting cells ( APC s) has been described, involving exchange of extracellular vesicles ( EV s) during the formation of the immunological synapse ( IS ). EV s, a term that encompasses exosomes and microvesicles, has been implicated in cell‐cell communication during immune responses associated with tumors, pathogens, allergies, and autoimmune diseases. This review focuses on EV transfer as a mechanism for the exchange of molecules during immune cell‐cell interactions.