Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Toxicological assessment of beta‐lapachone on organs from pregnant and non‐pregnant rats

2009; Wiley; Volume: 23; Issue: 9 Linguagem: Inglês

10.1002/ptr.2646

1099-1573

Reinaldo Nóbrega de Almeida, Flávia Raquel Santos Lucena, Camilla Vila Nova Soares Silva, Wilson da Silva Costa‐Junior, Jouse Bezerra Cavalcanti, Gerald Bosco Lindoso Couto, Luiz Lúcio Soares da Silva, Diógenes Luís da Mota, Alex Benício da Silveira, Samuel Daniel de Sousa Filho, Aldo Cezar Passilongo da Silva,

Synthesis and Biological Evaluation

Abstract Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. β ‐Lapachone (beta‐lap) is an o ‐naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta‐lap in Wistar rats observing the following parameters: teratology, histology, hematology and serum biochemistry. The data demonstrate teratogenic action at the doses used, as well as hematological alterations in the total leukocytes, monocytes and segmented. The biochemical data demonstrated an increase in gamma glutamyl transferase, alkaline phosphatase and glutamate pyruvate transaminase levels. Histological study showed significant alterations in the spleen, however, the liver and kidney did not present significant alterations. Copyright © 2009 John Wiley & Sons, Ltd.