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R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma

2015; Elsevier BV; Volume: 125; Issue: 9 Linguagem: Inglês

10.1182/blood-2014-10-604561

1528-0020

Antonio Omuro, Denise D. Correa, Lisa M. DeAngelis, Craig H. Moskowitz, Matthew J. Matasar, Thomas Kaley, Igor T. Gavrilovic, Craig Nolan, Elena Pentsova, Christian Grommes, Katherine S. Panageas, Raymond E. Baser, Géraldine Faivre, Lauren E. Abrey, Craig S. Sauter,

Moyamoya disease diagnosis and treatment

Key Points We conducted a phase-2 study in newly diagnosed PCNSL utilizing R-MPV and HDC with ASCT. Excellent disease control and OS (2-year PFS: 79%) were observed, with an acceptable toxicity profile and minimal neurotoxicity.