Synthesis and characterization of thiomers of polyaspartamide type
2004; Elsevier BV; Volume: 291; Issue: 1-2 Linguagem: Inglês
10.1016/j.ijpharm.2004.07.058
ISSN1873-3476
AutoresM. Bubenik Biličić, Jelena Filipović‐Grčić, Anita Martinac, Monika Barbarić, Branka Zorc, Biserka Cetina‐Čižmek, Petar Tudja,
Tópico(s)Advanced Polymer Synthesis and Characterization
ResumoSynthesis of poly[α,β-(N-2-hydroxyethyl-dl-aspartamide)]–thioglycolic acid (PHEA–TGA) conjugate as a new polyaspartamide thiomer is described. The parent polymer PHEA is chemically modified by introducing sulphydryl-bearing compound thioglycolic acid. By varying the reaction conditions several batches of PHEA–TGA conjugates were prepared and analyzed. Tensile studies revealed that total work of adhesion of PHEA–TGA increased more than twice compared to the unmodified polymer. Microparticles prepared from the thiolated polymer preserved its bioadhesive properties.
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