Measles case fatality by sex, vaccination status, and HIV-1 antibody in Zambian children
1996; Elsevier BV; Volume: 348; Issue: 9024 Linguagem: Inglês
10.1016/s0140-6736(05)65044-1
ISSN1474-547X
AutoresHitoshi Oshitani, Hiroshi Suzuki, Evans Mpabalwani, Katsumi Mizuta, Yoshio Numazaki,
Tópico(s)Immune responses and vaccinations
ResumoMeasles is known to be more severe in human immunodeficiency virus (HIV-1)-infected children. 1 Kaplan LJ Daum RS Smaron M McCarthy Severe measles in immunocompromized patients. JAMA. 1992; 267: 1237-1241 Crossref PubMed Scopus (293) Google Scholar In sub-Saharan Africa, measles is still a major cause of morbidity and mortality in infants and children, and HIV-1 infection is increasing rapidly in this age group. Measles prevention in HIV-infected children is an important public health issue. Measles vaccine has been shown to be immunogenic and not associated with increased severe acute adverse reactions in HIV-infected children, 2 Cutts FT Mandala K St Louis M et al. Immunogenicity of high-titer Edmonton-Zagreb measles vaccine in human immunodeficiency virus-infected children in Kinshasa, Zaire. J Infect Dis. 1993; 167: 1418-1421 Crossref PubMed Scopus (26) Google Scholar and its use has been recommended by WHO. 3 Global Program on AIDS and Expanded Program on Immunization Joint WHO/UNICEF statement on early immunization for HIV-infected children. MMWR Wkly Epidemiol Rec. 1989; 64: 48-49 Google Scholar However, long-term protective efficacy and safety of measles vaccine in HIV-infected African children is unknown.
Referência(s)