The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response
2005; Cold Spring Harbor Laboratory Press; Volume: 19; Issue: 19 Linguagem: Inglês
10.1101/gad.1324805
ISSN1549-5477
AutoresHideki Inoue, Naoki Hisamoto, Jae Hyung An, Riva de Paula Oliveira, Eisuke Nishida, T. Keith Blackwell, Kunihiro Matsumoto,
Tópico(s)Circadian rhythm and melatonin
ResumoThe evolutionarily conserved p38 mitogen-activated protein kinase (MAPK) cascade is an integral part of the response to a variety of environmental stresses. Here we show that the Caenorhabditis elegans PMK-1 p38 MAPK pathway regulates the oxidative stress response via the CNC transcription factor SKN-1. In response to oxidative stress, PMK-1 phosphorylates SKN-1, leading to its accumulation in intestine nuclei, where SKN-1 activates transcription of gcs-1 , a phase II detoxification enzyme gene. These results delineate the C. elegans p38 MAPK signaling pathway leading to the nucleus that responds to oxidative stress.
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