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Adenosine receptor agonists inhibit inositol phosphate accumulation in rat striatal slices

1987; Elsevier BV; Volume: 137; Issue: 2-3 Linguagem: Inglês

10.1016/0014-2999(87)90234-2

1879-0712

Douglas W. Petcoff, Dermot M.F. Cooper,

Regulation of Appetite and Obesity

The accumulation of inositol-1-phosphate in rat striatal slices was inhibited by the adenosine analogues 5′-N-ethyl-carboxamide-adenosine and N6-phenylisopropyladenosine. Maximal inhibition (approximately 20%) was achieved by micromolar concentrations of either compound. Both basal and stimulated values could be inhibited, and the inhibition was reversible by the adenosine receptor antagonist 8-phenyltheophylline (10 μM). The results suggest that adenosine may exert a tonic inhibitory influence on inositol phospholipid-derived second messenger production in the striatum in vivo.