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Carbodiimides inhibit the acid-induced purple-to-blue transition of bacteriorhodopsin

1980; Elsevier BV; Volume: 592; Issue: 3 Linguagem: Inglês

10.1016/0005-2728(80)90105-x

1879-2650

Robert Renthal, Bill Wallace,

Neuroscience and Neuropharmacology Research

Reaction of purple membrane with water soluble carbodiimides inhibits the spectral transition from purple to blue observed at acid pH. The pK and Hill constant for this transition are shifted from 3.4 to 2.6 and from 1.8 to 0.85, respectively. The results suggest a connection between the uptake side of the proton pump and the purple-to-blue transition.