ETHANOL'S ACTION ON THE GABA A RECEPTOR: IS THERE A REQUIREMENT FOR PARSIMONY?
1995; Wiley; Volume: 19; Issue: 6 Linguagem: Inglês
10.1111/j.1530-0277.1995.tb01032.x
ISSN1530-0277
Autores Tópico(s)Neuroscience and Neuropharmacology Research
ResumoAlcohol: Clinical and Experimental ResearchVolume 19, Issue 6 p. 1597-1598 ETHANOL'S ACTION ON THE GABAA RECEPTOR: IS THERE A REQUIREMENT FOR PARSIMONY? Boris Tabakoff Ph.D., Boris Tabakoff Ph.D. Department of Pharmacology University of Colorado School of Medicine Denver, COSearch for more papers by this author Boris Tabakoff Ph.D., Boris Tabakoff Ph.D. Department of Pharmacology University of Colorado School of Medicine Denver, COSearch for more papers by this author First published: December 1995 https://doi.org/10.1111/j.1530-0277.1995.tb01032.xCitations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. REFERENCES 1 DeFries JC, Wilson JR, Erwin VG, Petersen DR: LS × SS recombinant inbred strains of mice: Initial characterization. Alcohol Clin Exp Res 13: 196– 200, 1989. 2 Harris RA, McQuilkin SJ, Paylor R, Abeliovich A, Tonegawa S, Wehner JM: Mutant mice lacking the γ isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of γ-aminobutyrate type A receptors. Proc Natl Acad Sci USA 92: 3658– 3662, 1995. 3 Wafford, KA Burnett, DM, Leidenheimer NJ, Burt DR, Wang JB, Kofuji P, Dunwiddie TV, Harris RA, Sikela JM: Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires eight amino acids contained in the γ2L subunit of the receptor complex. Neuron 7: 27– 33, 1991. 4 Wafford KA, Whiting PJ: Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the γ2-subunit. FEBS Lett 313: 113– 117, 1992. 5 Weiner JL, Zhang L, Carlen PL: Potentiation of GABAA-mediated synaptic current by ethanol in hippocampal CA1 neurons: Possible role of protein kinase C. J Pharmacol Exp Ther 268: 1388– 1395, 1994. 6 Snell LD, Tabakoff B, Hoffman PL: Involvement of protein kinase C in ethanol-induced inhibition of NMDA receptor function in cerebellar granule cells. Alcohol Clin Exp Res 18: 81– 85, 1994. 7 Dildy-Mayfield JE, Harris RA: Ethanol inhibits kainate responses of glutamate receptors expressed in Xenopus oocytes: Role of calcium and protein kinase C. J Neurosci 15: 3162– 3171, 1995. 8 Messing RO, Petersen PJ, Henrich CJ: Chronic ethanol exposure increases levels of protein kinase C δ and and protein kinase C-mediated phosphorylation in cultured neural cells. J Biol Chem 266: 23428– 23432, 1991. 9 Dolin SJ, Little HJ: Are changes in neuronal calcium channels involved in ethanol tolerance J Pharmacol Exp Ther 250: 985– 991, 1989. 10 Dolin S, Little H, Hudspith M, Pagonis C, Littleton J: Increased dihydropyridine-sensitive calcium channels in rat brain may underlie ethanol physical dependence. Neuropharmacology 26: 275– 279, 1987. 11 Sigel E, Baur R, Malherbe P: Recombinant GABAA receptor function and ethanol. FEBS Lett 324: 140– 142, 1993. 12 Hoffman PL, Snell LD, Bhave SV, Tabakoff B: Ethanol inhibition of NMDA receptor function in primary cultures of rat cerebellar granule cells and cerebral cortical cells. Alcohol Alcoholism (in press). 13 Suzdak PD, Schwartz RD, Skolnick P, Paul SM: Ethanol stimulates γ-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc Natl Acad Sci USA 83: 4071– 4075, 1986. 14 Allan AM, Spuhler KP, Harris RA: γ-Aminobutyric acid-activated chloride channels: Relationship to genetic differences in ethanol sensitivity. J Pharmacol Exp Ther 244: 866– 870, 1988. 15 Lin AM-Y, Freund RK, Hoffer BJ, Palmer MR: Ethanol-induced depressions of cerebellar Purkinje neurons are potentiated by β-adrenergic mechanisms in rat brain. J Pharmacol Exp Ther 271: 1175– 1180, 1994. 16 Wafford KA, Burnett DM, Dunwiddie TV, Harris RA: Genetic differences in the ethanol sensitivity of GABAA receptors expressed in Xenopus oocytes. Science 249: 291– 293, 1990. 17 Palmer MR, Wang Y, Fossom LH, Spuhler KP: Genetic correlation of ethanol-induced ataxia and cerebellar Purkinje neuron depression among inbred strains and selected lines of rats. Alcohol Clin Exp Res 11: 494– 501, 1987. 18 Iyengar R: Molecular and functional diversity of mammalian Gs-stimulated adenylyl cyclases. FASEB J 7: 768– 775, 1993. 19 Hellevuo K, Yoshimura M, Mons N, Hoffman PL, Cooper DMF, Tabakoff B: The characterization of a novel human adenylyl cyclase which is present in brain and other tissues. J Biol Chem 270: 11581– 11589, 1995. Citing Literature Volume19, Issue6December 1995Pages 1597-1598 ReferencesRelatedInformation
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