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Isolierung, Struktur und Synthese des Metaboliten von Azapropazon‐dihydrat

1972; Wiley; Volume: 55; Issue: 3 Linguagem: Inglês

10.1002/hlca.19720550328

1522-2675

G. Mixich,

Analytical Methods in Pharmaceuticals

Abstract The renal excretion of AZAPROPAZONE‐DIHYDRATE (X) Handelsname: PROLIXAN®. Hersteller: Siegfried AG , Zofingen. by humans was investigated. Following oral administration a new substance was detected in the urine besides X by TLC. Both compounds were separated by preparative layer chromatography and shown to be unchanged X and its hydroxylated metabolite VIII. The structure of VIII was established by chemical and spectroscopic methods (IR., NMR.) and confirmed by synthesis (Scheme 1).