Apolipoprotein-E genotyping in diagnosis of Alzheimer's disease
1996; Elsevier BV; Volume: 348; Issue: 9025 Linguagem: Inglês
10.1016/s0140-6736(05)64588-6
ISSN1474-547X
AutoresB. A. Kakulas, Steve D. Wilton, V. Fabian, T.N. Jones,
Tópico(s)Amyloidosis: Diagnosis, Treatment, Outcomes
ResumoSaunders and colleagues (July 13, p 90) 1 Saunders AM Hulette C Welsh-Bohmer KA et al. Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease patients. Lancet. 1996; 348: 90-93 Summary Full Text Full Text PDF PubMed Scopus (215) Google Scholar present a series of 67 consecutive patients diagnosed as clinical Alzheimer's disease (AD) in whom the diagnosis was confirmed at necropsy. Surprisingly, the specificity of the apolipoprotein-E (APOE) ε4 allele for AD was 100%, which is much greater than previous estimates based on clinical extrapolations. We have done an analysis of all patients older than 55 years who were referred for necropsy. The clinical notes from 1985 onwards were reviewed by one of us (TMJ) for written record of AD as the probable or suspected diagnosis during life. Although this series was not as fully evaluated clinically for AD as that of Saunders and colleagues, the prevalence of necropsy confirmed AD was 82% according to the Khachaturian criteria (in earlier years) or the CERAD (Consortium to Establish a Registry for Alzheimer's Disease) criteria recently. 2 Roses AD Apolipoprotein E genotyping in differential diagnosis, not prediction, of Alzheimer's disease. Ann Neurol. 1995; 38: 6-14 Crossref PubMed Scopus (195) Google Scholar All 66 patients were thought to have AD at the time of death, and all were white. The distribution of the ε4 alleles was: Tabled 1 Allele ɛ 4/4 3/4 2/4 3/3 2/3 2/2 AD 5 19 1 23 6 0 Non AD 0 0 0 10 2 0 Open table in a new tab
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