A Poxvirus-Encoded Semaphorin Induces Cytokine Production from Monocytes and Binds to a Novel Cellular Semaphorin Receptor, VESPR
1998; Cell Press; Volume: 8; Issue: 4 Linguagem: Inglês
10.1016/s1074-7613(00)80552-x
ISSN1097-4180
AutoresMichael R. Comeau, Richard D. Johnson, Robert DuBose, Melissa Petersen, Patrick Gearing, Tim VandenBos, Linda Park, Terry Farrah, R. Mark L. Buller, Jeffrey I. Cohen, L Strockbine, Charles T. Rauch, Melanie K. Spriggs,
Tópico(s)Axon Guidance and Neuronal Signaling
ResumoThe vaccinia virus A39R protein is a member of the semaphorin family. A39R.Fc protein was used to affinity purify an A39R receptor from a human B cell line. Tandem mass spectrometry of receptor peptides yielded partial amino acid sequences that allowed the identification of corresponding cDNA clones. Sequence analysis of this receptor indicated that it is a novel member of the plexin family and identified a semaphorin-like domain within this family, thus suggesting an evolutionary relationship between receptor and ligand. A39R up-regulated ICAM-1 on, and induced cytokine production from, human monocytes. These data, then, describe a receptor for an immunologically active semaphorin and suggest that it may serve as a prototype for other plexin–semaphorin binding pairs.
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