Genomic Exploration of the Hemiascomycetous Yeasts: 19. Ascomycetes‐specific genes
2000; Wiley; Volume: 487; Issue: 1 Linguagem: Inglês
10.1016/s0014-5793(00)02290-0
ISSN1873-3468
AutoresAlain Malpertuy, Fredj Tekaia, Serge Casarégola, Michel Aigle, François Artiguenave, Gaëlle Blandin, Monique Bolotin‐Fukuhara, Elisabeth Bon, Philippe Brottier, Jacky de Montigny, Pascal Durrens, Claude Gaillardin, Andrée Lépingle, Bertrand Llorente, Cécile Neuvéglise, Odile Ozier-Kalogéropoulos, Serge Potier, William Saurin, Claire Toffano‐Nioche, Micheline Wésolowski‐Louvel, Patrick Wincker, Jean Weissenbach, Jean‐Luc Souciet, Bernard Dujon,
Tópico(s)Fermentation and Sensory Analysis
ResumoComparisons of the 6213 predicted Saccharomyces cerevisiae open reading frame (ORF) products with sequences from organisms of other biological phyla differentiate genes commonly conserved in evolution from ‘maverick’ genes which have no homologue in phyla other than the Ascomycetes. We show that a majority of the ‘maverick’ genes have homologues among other yeast species and thus define a set of 1892 genes that, from sequence comparisons, appear ‘Ascomycetes‐specific’. We estimate, retrospectively, that the S. cerevisiae genome contains 5651 actual protein‐coding genes, 50 of which were identified for the first time in this work, and that the present public databases contain 612 predicted ORFs that are not real genes. Interestingly, the sequences of the ‘Ascomycetes‐specific’ genes tend to diverge more rapidly in evolution than that of other genes. Half of the ‘Ascomycetes‐specific’ genes are functionally characterized in S. cerevisiae , and a few functional categories are over‐represented in them.
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