The effect of halofenate and clofibrate on aggregation and release of serotonin by human platelets
1976; Elsevier BV; Volume: 18; Issue: 6 Linguagem: Inglês
10.1016/0024-3205(76)90334-9
ISSN1879-0631
AutoresChu Yuan Lin, Stuart E. Smith,
Tópico(s)Inflammatory mediators and NSAID effects
ResumoThe hypolipidemic drugs halofenate and clofibrate inhibit the aggregation of human platelets induced by ADP, collagen and epinephrine. The effect of the drugs is primarily on the “second wave” of aggregation which is associated with the platelet release reaction. The drugs also inhibit the release of serotonin from platelets suggesting that the effect on aggregation is attributable to an inhibition of the release reaction. Halofenate is much more potent than clofibrate in inhibiting both the release of serotonin and the second wave of aggregation.
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