Reactivity of active centre analogues of Cu2Zn2-superoxide dismutase during the aqueous decay of K3CrO8
1989; Elsevier BV; Volume: 160; Issue: 1 Linguagem: Inglês
10.1016/s0020-1693(00)85411-0
ISSN1873-3255
Autores Tópico(s)Vanadium and Halogenation Chemistry
ResumoThe aqueous decay of K3CrO8 was used to compare the reactivity of Cu2Zn2-superoxide dismutase and two active centre analogues where the first shell atoms around the copper are four unsaturated nitrogens. Unlike the acetate- or biuret-type Cu(II) chelates these di-Schiff base complexes had an identical reactivity compared to that of the intact enzyme. Nanomolar concentrations of copper coordinated in these complexes were sufficient to inhibit the K3CrO8 induced chemiluminescence by 50%. They were also able to inhibit the hyaluronic acid degradation successfully by 27%.
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