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Cytokine production by mast cells and basophils

1991; Elsevier BV; Volume: 3; Issue: 6 Linguagem: Inglês

10.1016/s0952-7915(05)80005-6

1879-0372

Stephen J. Galli, John Gordon, Barry K. Wershil,

Immune Cell Function and Interaction

Mast cells and/or basophils have been implicated in the expression of a wide variety of biological responses, including immediate hypersensitivity reactions, host responses to parasites and neoplasms, angiogenesis, tissue remodeling, and immunologically non-specific inflammatory and fibrotic conditions. Recent findings suggest that an important mechanism by which mast cells influence such biological responses is through the production of a broad panel of multifunctional cytokines. In contrast, the extent to which basophils can produce cytokines is uncertain.