Association between the bovine major histocompatibility complex and chronic posterior spinal paresis – a form of ankylosing spondylitis – in Holstein bulls
1993; Wiley; Volume: 24; Issue: 1 Linguagem: Inglês
10.1111/j.1365-2052.1993.tb00919.x
ISSN1365-2052
AutoresC A Park, H. C. Hines, Donald R. Monke, WilliamJ. Threlfall,
Tópico(s)Spine and Intervertebral Disc Pathology
ResumoA highly significant association was found between the bovine MHC class I antigen BoLA-A8 and a form of vertebral osteophytosis/ankylosing spondylitis known as chronic posterior spinal paresis (PSP) in Holstein bulls (P < 0.001). In a population study, restricted to unrelated bulls, BoLA-A8 was significantly associated with PSP (P = 0.0015) with a relative risk of 34.6. In a family study, one PSP bull, BoLA A8/A20, sired 13 offspring. BoLA-A8 was significantly associated with PSP (P = 0.0008). All five PSP sons inherited the A8 allele and the eight healthy sons each inherited the A20 allele. In three other families a complete association of BoLA-A8 and PSP was observed. Lod score analysis, using all available families, indicated a significant linkage between BoLA and PSP (lod score = 6.9). Based on clinical observation, pathology, age/sex predilection, and a strong association with a class I MHC molecule, this inflammatory disease appears analogous to the human condition known as ankylosing spondylitis.
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