Desorption electrospray ionization mass spectrometry for lipid characterization and biological tissue imaging
2011; Elsevier BV; Volume: 1811; Issue: 11 Linguagem: Inglês
10.1016/j.bbalip.2011.05.006
ISSN1879-2618
AutoresLívia S. Eberlin, Christina R. Ferreira, Allison L. Dill, Demian R. Ifa, R. Graham Cooks,
Tópico(s)Metabolomics and Mass Spectrometry Studies
ResumoDesorption electrospray ionization mass spectrometry (DESI-MS) imaging of biological samples allows untargeted analysis and structural characterization of lipids ionized from the near-surface region of a sample under ambient conditions. DESI is a powerful and sensitive MS ionization method for 2D and 3D imaging of lipids from direct and unmodified complex biological samples. This review describes the strengths and limitations of DESI-MS for lipid characterization and imaging together with the technical workflow and a survey of applications. Included are discussions of lipid mapping and biomarker discovery as well as a perspective on the future of DESI imaging.
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