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Vertical transmission of Kaposi's sarcoma-associated herpesvirus

2001; Wiley; Volume: 94; Issue: 5 Linguagem: Inglês

10.1002/ijc.1529

1097-0215

Hamakwa Mantina, Chipepo Kankasa, Winslow Klaskala, Brad Brayfield, James J. Campbell, Quijiang Du, Ganapati Bhat, Francis Kasolo, Charles D. Mitchell, Charles Wood,

Cytomegalovirus and herpesvirus research

Little is presently known about the specific routes of transmission of Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8). To investigate whether this agent might be transmitted vertically from mother to infant, we conducted a study on 89 KSHV seropositive mothers and their newborn infants. Thirteen mothers (14.6%) had KSHV DNA detected in their peripheral blood mononuclear cells (PBMC). Two of 89 samples drawn at birth from infants born to KSHV seropositive mothers had KSHV DNA detectable within their PBMC. These findings suggest that KSHV can be transmitted perinatally, but infrequently. Other routes of transmission such as horizontal transmission remain the most likely means of KSHV transmission. © 2001 Wiley-Liss, Inc.