Portal de Periódicos da CAPES

Linite plastique gastrique

2007; Elsevier BV; Volume: 36; Issue: 12 Linguagem: Inglês

10.1016/j.lpm.2007.03.004

2213-0276

Mohamed Issam Beyrouti, Ramez Beyrouti, Mohamed Ben Amar, Foued Frikha, Rahma Beyrouti, Mohamed Abid, Khalil Ben Salah, Salah Boujelben,

Cancer Diagnosis and Treatment

Linitis plastica accounts for 3-19% of gastric cancers. Its diagnosis requires morphology findings of an infiltrating stomach tumor and pathology findings including signet-ring cells and fibrous stroma. Its etiology is not known, and it has no particular features. Diagnostic sensitivity of endoscopy is poor because of the difficulty of biopsies: "Forceps slide on the infiltrated walls." Its characteristic radiologic appearance is due to the infiltration and stiffness that causes it to be known as "leather-bottle stomach". Endosonography is currently the reference examination and has made it possible to identify localized linitis. Unlike other stomach cancers, it frequently extends into the peritoneum and lymphatic system. Curative treatment remains radical surgical resection. Modern chemotherapy protocols based on oral derivatives of 5-FU (TS-1) and of paclitaxel appear promising. The severity of its prognosis is explained by the frequency of peritoneal dissemination, lymphatic invasion and extension toward neighboring organs.