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Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8 + T cells

2009; Elsevier BV; Volume: 278; Issue: 2 Linguagem: Inglês

10.1016/j.canlet.2009.01.015

1872-7980

Ho‐Keun Kwon, Won Kyung Jeon, Jisun Hwang, Choong‐Gu Lee, Jae‐Seon So, Jina Park, Byoung‐Seob Ko, Sin‐Hyeog Im,

Bioactive Compounds and Antitumor Agents

Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8+ T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment.