Portal de Periódicos da CAPES

In vitro activity of cefditoren and other antimicrobial agents against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in Zaragoza, Spain

2008; Elsevier BV; Volume: 62; Issue: 2 Linguagem: Inglês

10.1016/j.diagmicrobio.2008.06.007

1879-0070

Cristina Seral, Laura Navarro Suarez, Carmen Rubio-Calvo, R Gómez-Lus, Mercedes Gimeno, Pilar Coronel, Estrella Durán, Raquel Becerril, Mercedes Oca, Francisco Javier Castillo,

Antibiotic Resistance in Bacteria

In vitro cefditoren antimicrobial activity was tested against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in our hospital from January 2005 to May 2006 by agar dilution and broth microdilution method, respectively. MICs were also determined for 13 and 10 comparison drugs, respectively. The pneumococci tested comprised 113 (39.2%) penicillin susceptible, 91 (31.6%) penicillin intermediate, and 84 (29.2%) penicillin resistant. Cefditoren was the most active drug on the basis of the MICs (MIC(90)=0.5 microg/mL), followed by ceftriaxone and levofloxacin (MIC(90)=1 microg/mL). Cefditoren MICs ranged from 0.25 to 1 microg/mL for ceftriaxone-resistant isolates, with a modal MIC of 0.5 microg/mL and an MIC(90) of 1.0 microg/mL. No S. pneumoniae isolates evaluated in this study showed MICs to cefditoren higher than 1 microg/mL (MIC range, <or=0.015 to 1 microg/mL). Against penicillin-resistant pneumococci, the rank order of intrinsic activity (MIC(90), microg/mL) was cefditoren (0.5)<ceftriaxone (2.0)=cefotaxime (2.0) 4 microg/mL). Against H. influenzae (Hi beta+), the rank order of intrinsic activity (MIC(90), microg/mL) was cefditoren (0.03) < cefixime (0.06)<ceftriaxone (0.12)=cefotaxime (0.12)<cefuroxime (1.0)<amoxicillin/clavulanate (2.0) 8.0).