Copper-Catalyzed Decarboxylative C–P Cross-Coupling of Alkynyl Acids with H -Phosphine Oxides: A Facile and Selective Synthesis of ( E )-1-Alkenylphosphine Oxides
2014; American Chemical Society; Volume: 16; Issue: 17 Linguagem: Inglês
10.1021/ol502009b
ISSN1523-7060
AutoresGaobo Hu, Yuxing Gao, Yufen Zhao,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoA novel and efficient copper-catalyzed decarboxylative cross-coupling of alkynyl acids for the stereoselective synthesis of E-alkenylphosphine oxides has been developed. In the presence of 10 mol % of CuCl without added ligand, base, and additive, various alkynyl acids reacted with H-phosphine oxides to afford E-alkenylphosphine oxides with operational simplicity, broad substrate scope, and the stereoselectivity for E-isomers.
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