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Quinolines derivatives as novel sunscreening agents

2013; Elsevier BV; Volume: 23; Issue: 16 Linguagem: Inglês

10.1016/j.bmcl.2013.06.046

1464-3405

Hudson Polonini, Rafael M. P. Dias, Isabela O. Souza, Karla Mara Gonçalves, Tiago Braga Gomes, Nádia Rezende Barbosa Raposo, Adilson David da Silva,

Olfactory and Sensory Function Studies

Currently, the research and development of sunscreens play an important role on the synthesis of actives that are stable in various kinds of formulations-in addition to their efficiency and broad spectrum of protection against ultraviolet radiation. Our objective here was to synthesize new sunscreening chemical agents using quinoline as a base molecule. Twelve quinoline derivatives were synthesized, four of them novel molecules, and their photoprotective activity was determined in vitro using diffuse transmittance spectrophotometry. We determined their SPF, UVAPF, UVA/UVB ratio, critical wavelength and Boots Star Rating. The quinolines derivatives presented a varied profile of photoprotection, their SPF ranging from 2 to 11 and their UVAPF from 2 to 7. In terms of the critical wavelength, all molecules were considered of broad-spectrum by different classifications. Regarding the Boots Star Rating, one compound received no rating, seven of them received a three stars rating, three received a four stars rating and three were given a five stars rating. The molecules showed in the present work have a wide range of possibilities for creating new sunscreen products, once they have good SPF or UVAPF for single molecules, and they also possess other different qualities that can act synergistically.