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Cell Adhesion Proteins As Tumor Suppressors

2002; Lippincott Williams & Wilkins; Volume: 167; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(05)65245-7

1527-3792

Takatsugu Okegawa, Yingming Li, Rey-Chen Pong, Jer‐Tsong Hsieh,

Galectins and Cancer Biology

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Apr 2002Cell Adhesion Proteins As Tumor Suppressors Takatsugu Okegawa, Yingming Li, Rey-Chen Pong, and Jer-Tsong Hsieh Takatsugu OkegawaTakatsugu Okegawa , Yingming LiYingming Li , Rey-Chen PongRey-Chen Pong , and Jer-Tsong HsiehJer-Tsong Hsieh View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65245-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We summarize recent progress on the role of cell adhesion molecules in biology and discuss the potential application of cell adhesion molecules for managing urological cancer. Materials and Methods: We comprehensively reviewed the literature from 1982 to 2001, including peer reviewed publications and recent abstracts from national meetings, relevant to cell adhesion molecules in urological cancer. Results: A growing body of evidence suggests that alterations in the adhesion properties of neoplastic cells have a pivotal role in the development and progression of cancer. Loss of intercellular adhesion and desquamation of cells from the underlying lamina propria allows malignant cells to escape from their site of origin, degrade the extracellular matrix, acquire a more motile and invasion phenotype, and invade and metastasize. In addition to participating in tumor invasiveness and metastasis, adhesion molecules regulate or significantly contribute to various functions, including signal transduction, cell growth, differentiation, site specific gene expression, morphogenesis, immunological function, cell motility, wound healing and inflammation. To date a diverse system of transmembrane glycoproteins has been identified that mediates cell-cell and cell-extracellular matrix adhesion. The main families of adhesion molecules include members of the Ig superfamily, cadherins, integrins and selectins. Conclusions: Multiple and diverse cell adhesion molecules participate in intercellular and cell-extracellular matrix interactions of cancer. Cancer progression is a multistep process, in which some adhesion molecules have a pivotal role in the development of recurrent, invasive and distant metastasis. Recent data implicate some of these molecules in cell signaling and tumor suppression, which has important consequences for tumor growth. References 1 : Cellular adhesion molecules in urologic malignancies. Am J Clin Pathol1997; 107: 56. Google Scholar 2 : In vitro modulation of tumor progression-associated properties of hormone refractory prostate carcinoma cell lines by cytokines. Cancer1996; 77: 1862. Google Scholar 3 : Levels of circulating intercellular adhesion molecule-1 in patients with metastatic cancer of the prostate and benign prostatic hyperplasia. 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Google Scholar From the Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byXu B, He Y, Wu X, Luo C, Liu A and Zhang J (2018) Exploration of the Correlations Between Interferon-γ in Patient Serum and HEPACAM in Bladder Transitional Cell Carcinoma, and the Interferon-γ Mechanism Inhibiting BIU-87 ProliferationJournal of Urology, VOL. 188, NO. 4, (1346-1353), Online publication date: 1-Oct-2012.Huygens A, Crnolatac I, Develter J, Van Cleynenbreugel B, Van der Kwast T and de Witte P (2018) Differential Accumulation of Hypericin in Spheroids Composed of T-24 Transitional Cell Carcinoma Cells Expressing Different Levels of E-CadherinJournal of Urology, VOL. 179, NO. 5, (2014-2019), Online publication date: 1-May-2008.HUYGENS A, KAMUHABWA A, ROSKAMS T, VAN CLEYNENBREUGEL B, VAN POPPEL H and de WITTE P (2018) PERMEATION OF HYPERICIN IN SPHEROIDS COMPOSED OF DIFFERENT GRADE TRANSITIONAL CELL CARCINOMA CELL LINES AND NORMAL HUMAN UROTHELIAL CELLSJournal of Urology, VOL. 174, NO. 1, (69-72), Online publication date: 1-Jul-2005. Volume 167Issue 4April 2002Page: 1836-1843 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordsurologic neoplasmscell adhesion moleculesurinary tractMetricsAuthor Information Takatsugu Okegawa More articles by this author Yingming Li More articles by this author Rey-Chen Pong More articles by this author Jer-Tsong Hsieh More articles by this author Expand All Advertisement PDF downloadLoading ...